Cytotoxic Activity of Ethyl Acetate Extract from Voacanga foetida (Bl.) Rolfe Leaves Against T47D Breast Cancer Cells

The cytotoxicity of ethyl acetate extract from Tampa badak (Voacanga foetida (Bl.) Rolfe) leaves against Artemia salina leach larvae was determined using the brine shrimp lethality test (BSLT) method and evaluated T47D breast cancer cells MTT assay method. result BSLT showed a consistent with assay, which is obtained that very toxic A. Leach LC50 value 8.61 µg/mL cytotoxic IC50 values 0.87; 0.66; 0.95 at 24, 48 72 hours incubation times, respectively. data were analyzed two-way ANOVA statistical to see effect dependent variable (concentration time) on independent (% viability). Based result, there difference in % viability between concentrations 0.1; 1; 10 (p <0.05), but length does not affect >0.05).